Cannabidiol (CBD) is a naturally occurring compound found in cannabis – a plant with an intimate and industrious relationship with us since the beginning of human history. CBD is one of ~140+ unique chemicals found in cannabis called phytocannabinoids (“plant-made cannabinoid”). In 1992(!), the chemical structure of THC and CBD was determined, leading scientists to quickly find two similar chemicals made naturally in humans and animals – calling them endocannabinoids (“made-inside cannabinoids”, 2-AG and Anandamide). While there are volumes of detailed therapeutic uses in the historical record, modern science is just now unraveling the secrets of how these chemicals interact with our body via the Endocannabinoid System (ECS).


CBD vs THC – will it make me feel “high”?

Although chemical cousins, THC & CBD have significantly different effects. This is based on how each interacts with the endocannabinoid system. THC interacts with the CB1 receptor found densely throughout the central nervous system. When THC binds to CB1, it activates the receptor initiating a cascade of downstream activity ranging from control of gene expression to behavioral and cognitive effects. CBD does not have an activating interaction with CB1 and thus does not produce the same “high” feeling commonly associated with cannabis. In fact, it is believed that CBD prevents or minimizes THC from activating CB1 receptors limiting the intensity of THC’s psychoactive effects.

Why are people taking CBD?

Anecdotal reports and clinical research support a wide range of therapeutic benefits from CBD, including neuroprotection, anti-inflammatory, and analgesic (pain reducing) properties as well as value in the management of mood and motivational disorders like depression, anxiety, and addiction.

It’s very important to realize that the recent “CBD craze” can make it seem like the return of snake oil. Cannabis & CBD is not a cure-all or a panacea. Research into therapeutic activity remains ongoing and very early (for modern scientific approaches). The effectiveness of CBD or lack-thereof can vary based on individual conditions & circumstances.

Another factor to consider regarding the therapeutic use of CBD is based on it’s broad and unbroken safety track record. In other words, individuals interesting in trying CBD may experience zero to life-altering benefits. For example, reducing daily seizure occurrences from 1000s to single digits significantly improves life quality for those affected by these epileptic episodes. At the same time, CBD treatments do not eliminate seizure symptoms universally, in every single case, even using identical product formulations in the exact same way. Luckily, individuals are now able to try CBD on their own terms without breaking the law or exposing themselves/loved ones to any serious medical risks. This makes the risk/reward calculation straight forward – stand to benefit from giving it a try, without concern that it could make things worse. A striking difference from the side-effect laundry lists read quickly in contemporary pharmaceutical commercials.

Humans have practically been linked up with the cannabis plant from the dawn of history – for nutritional, industrious and medical purposes. In fact, some prominent researchers postulate that humans and cannabis co-evolved – meaning our genetic code and the plants were actually modified due to how long and how closely we have co-existed. Since this humble beginning, not one human has died directly from cannabis consumption. This safety profile and track record continue to this day – not one human death has ever be attributed to cannabis or cannabinoid exposure. No chance of death or serious, permanent adverse reactions, with a plausible chance of minor to significant improvements in your or a loved one’s quality of life.

Additional Information
Understanding CBD Part 1, Part 2, Part 3 –
How cannabis fights inflammation –

More Zativa CBD Resources